MUCOADHESIVE IN SITU RECTAL GEL LOADED WITH RIFAMPICIN: STRATEGY TO IMPROVE BIOAVAILABILITY AND ALLEVIATE LIVER TOXICITY

Mucoadhesive In Situ Rectal Gel Loaded with Rifampicin: Strategy to Improve Bioavailability and Alleviate Liver Toxicity

Although it is a front-line in tuberculosis treatment, rifampicin (RF) exhibits poor oral bioavailability and hepatotoxicity.Rectal mucoadhesive and in situ rectal gels were developed to babyliss berry crush 230 overcome drug drawbacks.A RF/polyethylene glycol 6000 co-precipitate was first prepared in different ratios.Based on the drug solubility,

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The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 1; peer review: 4 approved]

This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator.It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by circulating concentrations dodge challenger fog light cover of this gonadotropin, were first observed

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Ribosome biogenesis disruption mediated chromatin structure changes revealed by SRAtac, a customizable end to end analysis pipeline for ATAC-seq

Abstract The nucleolus is a large nuclear body that serves as the primary site for ribosome biogenesis.Recent studies have suggested that it also plays an important role in organizing chromatin architecture.However, to establish a causal relationship boneflesh d2 between nucleolar ribosome assembly and chromatin architecture, genetic tools are requ

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